Talk with your doctor before you stop taking TRIBENZOR. Take TRIBENZOR as prescribed by your doctor. Some of your other medicines and TRIBENZOR could affect each other. Your blood pressure may become too low if you drink alcohol. If you are taking TRIBENZOR, do not drink alcohol. CYP3A inhibitors and CYP3A inducers (medicines that affect the liver)Ībout alcohol and other drug interactions.Cyclosporine or tacrolimus (medicines used to alter the way your immune system works).Cholesterol-lowering medicines (including simvastatin).Lithium for certain types of depression.Sleeping pills and antiseizure medicines called barbiturates.Pain or arthritis medicines, such as aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs).Potassium supplements or a salt substitute that contains potassium.Other medicines for high blood pressure or a heart problem.If you take TRIBENZOR, tell your doctor if you also take: These medicines may include prescription and nonprescription medicines, vitamins, and herbal supplements: Tell your doctor about all the medicines you take Heart problems (including coronary heart disease and narrowing of the aortic valve).Let your doctor know if you have these, or any other, medical conditions: Also let your doctor know if you have any of the health conditions listed below: Tell your doctor if you are allergic to any of the ingredients in TRIBENZOR (see Full Product Information for a list of the ingredients in TRIBENZOR). Let your doctor know about any health conditions you may have (Please see Boxed WARNING regarding Fetal Toxicity). You and your doctor should decide if you will take TRIBENZOR or breast-feed. A medicine in TRIBENZOR can pass into your breast milk. Also tell your doctor if you are breast-feeding or plan to breast-feed. Have not taken any other medicines to treat your high blood pressure beforeĬhildren of any age should not receive TRIBENZOR.īefore taking TRIBENZOR, tell your doctor if you are pregnant or plan to become pregnant as soon as possible.Are allergic to other sulfonamide type medicines.Are allergic to any component of this medicine.Have less urine than normal or if you cannot urinate.Take medicine that contains aliskiren and you have diabetes or kidney problems.Please see the WARNINGS AND PRECAUTIONS section of the Full Product Information about Fetal Toxicity. If you get pregnant while taking TRIBENZOR, tell your doctor immediately.Talk with your doctor about other ways to lower your blood pressure if you become pregnant.TRIBENZOR can cause harm or death to an unborn baby.This will be followed by a three-year period of residual payments for Forest during which it will no longer co-promote the product.WARNING: DO NOT TAKE TRIBENZOR DURING PREGNANCY Daiichi Sankyo will bear all marketing and development expenses and both firms are to co-promote Azor during the first three years of the deal. Under the terms of the six-year deal, Forest will pay Daiichi Sankyo an upfront payment of $20 million and will receive an annual co-promotion sum based upon US product net sales. Just last month the company announced that is had signed up Forest Laboratories to co-promote the drug in the USA. It will give physicians a new treatment option for patients whose blood pressure remains too high on currently prescribed medications,” he explained. “Azor, with its established efficacy and favourable side effect profile, provides two complementary mechanisms of action to lower blood pressure. “Azor is a valuable treatment addition, since so many people in the United States with hypertension do not have their blood pressure adequately controlled,” commented Michael Weber, Professor of Medicine at State University of New York, Downstate College of Medicine. Moreover, when pitted against amlodipine 10mg alone, Azor 10/40mg resulted in a 53% greater reduction in the mean change of systolic blood pressure, the group claims. In the pivotal registration trial, Azor 10/40mg cut systolic blood pressure an average of 30.1mm Hg and diastolic by 19.0mm Hg. The drug has certainly demonstrated its promise in clinical studies, inducing significant reductions in blood pressure in patients with hypertension. The Food and Drug Administration has given Japanese drugmaker Daiichi Sankyo the go-ahead to launch its new high blood pressure drug Azor on the US market.Īzor is a fixed-dose combination of two antihypertensives – the calcium channel blocker amlodipine (Pfizer’s Norvasc which recently went off-patent in the USA) and Daiichi Sankyo’s angiotensin receptor blocker Benicar (olmesartan), offering a double-edged attack on the condition.
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